Androgen Biosynthesis Inhibitors between 0(2) and H(l) and a H bond type linkage (albeit a strong one) between 0(3) and H(l).The very strong interactions of this arrangement are partially relieved in 2 ways. As in the KHMal, KHClMal, and maleic acid structures the internal angles of the ring system are strained considerably. The two angles 0(2)-C(l)-C(2) and 0(3)-C(4)-C(3) are not significantly different from each other and average 119°36' ± 42'. Similarly the angles C(l)-C(2)-C(3) and C(2)-C(3)-C(4) are insignificantly different and average 130°24' ± 24'. These angles are however significantly different from their unstrained counterparts of 121°18' and 121°3 0', respec-