Measurement of stimulated Tg combined with neck ultrasonography after total thyroidectomy may exclude the need for ablation in 56% of low-risk patients without TgAb (Tg <1 ng/mL) and permit the administration of an activity of 1.1 GBq ¹³¹I in another 34% with low Tg levels.

rhTSH is as effective as THW for RA in patients with WDTC who are at a high risk of relapse.

Objective: To establish limits of normal serum TSH for the adult (18 to 60 years) Brazilian population according to recommendations of the National Academy of Clinical Biochemistry. Subjects and methods: Healthy volunteers were evaluated and those fulfilling the following clinical criteria were selected: absence of known thyroid disease; no use of any interfering medications; no history of head and neck external radiotherapy, type 1 diabetes or autoimmune disease; no family history of thyroid disease, and absence of goiter or palpable nodules. Subjects with anti-thyroperoxidase antibodies and/or altered free T4 were excluded. The sample consisted of 960 subjects (480 males and 480 females). Results: TSH values corresponding to the 2.5th and 97.5th percentiles of the sample were 0.43 and 3.24 mIU/L, respectively. TSH values > 2.5 mIU/L were observed in 9.15% of the volunteers and levels > 3 mIU/L in 3.11%. Conclusion: The present study suggests an upper limit of normal TSH of approximately 3.5 mIU/L. Arq Bras Endocrinol Metab. 2010;54(7):603-6 Keywords TSH; reference values; adult population RESUMO Objetivo: Estabelecer os limites de normalidade do TSH sérico em uma população adulta (18 a 60 anos) brasileira, conforme as recomendações da National Academy of Clinical Biochemistry. Sujeitos e métodos: Inicialmente foram avaliados voluntários saudáveis e selecionados aqueles sem doença tireoidiana conhecida, uso de medicamentos interferentes, passado de radioterapia externa de cabeça e pescoço, diabetes tipo 1 ou doença autoimune, história familiar de doença tireoidiana, bócio ou nódulos palpáveis. Indivíduos com anticorpos antitireoperoxidase (TPOAb) e/ou T4 livre alterado foram excluídos. A amostra foi composta de 960 participantes (480 de cada sexo). Resultados: Os valores correspondentes aos percentis 2,5 e 97,5 da amostra foram 0,43 e 3,24 mIU/L, respectivamente. TSH > 2,5 mIU/L foi visto em 9,15% dos indivíduos e > 3 mIU/L em 3,11%. Conclusão: Nosso estudo sugere para a população adulta brasileira o limite superior normal do TSH de aproximadamente 3,5 mIU/L. Arq Bras Endocrinol Metab. 2010;54(7):603-6 Descritores TSH; valores de referência; população adulta

Low (131)I activity after rhTSH is effective for remnant ablation in patients who are at low risk of recurrence.

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