No abstract

No abstract

No abstract

A number of 2-substituted-a-i and -0-2'-deoxyadenosines have been prepared, and their growth inhibitory activity against leukemia L-1210, Streptococcus faecium, and Escherichia coli has been evaluated in vitro. Fusion of 2,6-dichloropurine with 1,3,5-tri-0-acety 1-2-deoxy-D-erythro-pentofuranose or with methyl 3,5-di-0-p-toluyl-2-deoxy-D-eryf/vo-pentofuranoside gave the anomeric mixtures of the acetyl-(80%) or p-toluyl-(30%) blocked deoxynucleosides. The acetylated mixture was treated with liquid ammonia, and the resulting2-chloro-2'-deoxy-

No abstract