Introduction: Autoimmune hepatitis is a rare condition that is increasingly reported in the literature. The absence of Gabonese data prompted this study, and the objective was to determine the profile of autoimmune hepatitis in Libreville.Patients and methods: This is a multicenter, cross-sectional study from January 2013 to December 2018. Foe this study we included patients followed for chronic liver disease in the hepato-gastroenterology and internal medicine departments of the CHU de Libreville, the internal medicine departments of Omar Bongo Ondimba Military Training Hospital, and the El Rapha Polyclinic, meeting the diagnostic criteria of the International Autoimmune Hepatitis Group simplified in 2008.Results: Among the 252 patients followed for hepatopathy in these centers, 11 met the diagnostic criteria, which is 4.4% as hospital frequency. The median age was 26years. The sex ratio was 2 men for 9 women. Autoimmune hepatitis type 1, with 8 cases (72.7%), was the most common type. It was associated with another autoimmune disease in 6 patients (54.5%). Primary biliary cholangitis accounted for half of the associated autoimmune diseases. The treatment was based on the combination of corticosteroids and Azathioprine in 8 patients (72.7%) and on corticosteroids alone in 3 patients. Conclusion:Autoimmune hepatitis is pathology, which is certainly rare but present in Libreville that affects young women. It is frequently associated with other autoimmune diseases.

Introduction:The cost of clinical treatment for Decompensated Cirrhosis is unknown in our context while it is fundamental in the therapeutic strategy. The objective of this work was to determine the cost of clinical treatment for Cirrhosis at the University Hospital Center of Libreville.Patients and methods: This is a retrospective study conducted from May 30, 2016 to September 30th 2018 in the hepato-gastroenterology department at Hospital University Center of Libreville. We included Cirrhotic patients who had at least one episode of decompensation during the study period. The data analyzed were socio-demographic, clinical, prognostic and etiological. The cost of treatment combined the costs of accommodation, additional examinations and treatment. Statistical analysis was performed using StaView SAS software version 5.0.Results: Decompensated Cirrhosis accounted for 57.7% of hospitalizations. It affected 167 hospitalized patients on average 3.5. There were 102 men and 65 women. The average age was 50years old. 47.3% were unemployed. 11.5% were students, 24.5% were Officials and 16.7% were engaged in various professional activities. Ascites (62.2%) and digestive hemorrhage (53.9%) were the most common modes of decompensation. According to the Child-Pugh classification, 55.7% of patients were classified C. The average length of hospital stay was 21days. The cost of clinical treatment for Cirrhotic Decompensation therefore varied between 685,000 FCFA (1,047 euros) and 1,039,000 FCFA (1,925.9 euros). Conclusion:Decompensated Cirrhosis is a frequent condition, the leading cause of hospitalization in the hepato-gastroenterology's department. Its clinical management is expensive and occurs in poor patients.