Counterfeit medicines are fake medicines which are either contaminated or contain the wrong or no active ingredient. Up to 30% of medicines in developing countries are counterfeit. Using Supervised Machine learning techniques we build a predictive model for predicting sales figures given other information related to counterfeit medicine selling operations. Thus, by predicting the values we can identify these illegal operations and counter them. In this paper we have also mentioned the importance of Data mining and Machine Learning algorithms with some comparison analysis.