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Drought is a disaster around the world accumulating salt and ero-sion in lands. Presently, a research was conducted to determine the morpho-physiological response in bread wheat under normal and stress irrigations. This experiment was conducted at the experimental field of Sindh Agriculture University, Tandojam, Hy-derabad, Pakistan, for two consecutive years during the Rabi season of the year 2011-12 and 2012-13. Stress was imposed by withhold-ing irrigations at three different growth stages of the plant, i.e. T1: normal irrigations applied, T2: stress at tillering stage, and T3: stress at the booting stage. The progenies Sarsabz x Khirman and Sarsabz x TD-1 contributed the highest heritability% (81.0% and 85.5%) for osmotic potential (-MPa) at stress at booting stage. For grain yield spike-1(g), the progeny Kiran-95 x Khirman showed maximum her-itability as 84.37 in T3. However, the progeny TD-1 x Imdad proved to be the best combiner progeny indicating highest heritability per-centage (91.0%) among the progenies for grain yield at booting stress.