The main purpose of this manuscript is to present some new estimations of the Jensen gap in a discrete sense along with their applications. The proposed estimations for the Jensen gap are provided with the help of the notion of 6-convex functions. Some numerical experiments are performed to determine the significance and correctness of the intended estimates. Several outcomes of the main results are discussed for the Hölder inequality and the power and quasi-arithmetic means. Furthermore, some applications are presented in information theory, which provide some bounds for the divergences, Bhattacharyya coefficient, Shannon entropy, and Zipf–Mandelbrot entropy.