Background: Diabetes mellitus is a clinical syndrome characterized by hyperglycemia caused by absolute or relative deficiency of insulin. The present study was conducted to compare PRP and conventional dressing in management of diabetic foot ulcer. Subjects and Methods: The present study was conducted on 120 patients with diabetic foot ulcers. Patients were divided into 2 groups of 60 each. Group I was those who received conventional dressing and group II patients received PRP dressings. Patients were examined and recalled regularly to see effect of dressing and size of the lesions. Results: Common site was mid foot seen in 35 and 30 in group II, fore foot seen 20 in group I and 18 in group II, hind foot seen 5 in group I and 12 in group II. The difference was non-significant (P> 0.05). At 0 week mean size of DFU was 4.2 mm in group I and 4.1 mm in group II, at 1 week was 4.0 mm in group I and 3.8 mm in group II, at 3rd week was 3.6 mm in group I and 2.4 mm in group II and 2.6 mm in group I and 1.2 mm in group II. The difference was significant (P< 0.05). Conclusion: Platelet rich plasma was effective in the management of diabetic foot ulcer. There was comparatively increase in size reduction in PRP group than conventional group.

To plan therapies for Hepatocellular Carcinoma (HCC), staging methods are necessary. The most often employed HCC management recommendation is the Barcelona Clinic Liver Cancer (BCLC) staging system. Transarterial Chemoembolisation (TACE) is the go- to therapy for BCLC stage B (intermediate HCC). Numerous studies back the use of TACE in individuals with early and advanced HCC. TACE may be an option for individuals who are not candidates for Radiofrequency Ablation (RFA) or Hepatic Resection (HR) for BCLC stage 0 (very early HCC). TACE with RFA offers superior local tumour suppression than RFA alone in BCLC stage. Patients awaiting liver transplants may benefit from TACE as a bridging treatment. When compared to supportive care approaches, TACE improves survival for BCLC-B patients. Patients with BCLC-C stage HCC are treated in the first instance with sorafenib. The combination of sorafenib and TACE has demonstrated efficacy in slowing the development of tumours. Patients with HCC and portal venous thrombosis have superior survival results with TACE combined with radiation. Taking all of these facts into account, it is obvious that TACE, either alone or in conjunction with other therapies, plays a crucial part in the treatment of HCC at every stage. Patients with HCC should get a variety of treatments, and the best TACE candidates should be chosen using a more accurate patient classification approach.

Introduction: All over world Intestinal obstruction is a common surgical emergency. Intra-abdominal problems are one of the most common as Intestinal Obstruction by general surgeons in their practice. Intestinal obstruction is defined as obstruction in forward propulsion of contents of the intestine either due to active or inactive or pseudo-obstruction. It is predisposed by varying underlying abnormality diseases that are difficult to define pre-operatively. About 12% to 16% of acute abdominal emergencies may be contributed to intestinal obstruction. With multiple etiologies for intestinal obstruction of either the small or large bowel which become to be a major cause of morbidity and mortality. There are various Mode of presentation for intestinal obstruction underlying various cause in each age group. In ancients period mortality and morbidity was very high. Nowadays due to improvement and understanding of pathophysiology, diagnosis techniques of radiology, electrolyte imbalance and high degree of refinement in correction of fluid, introduction of antibiotics to effective bacteriological control, introduction of techniques in gastrointestinal decompression, introduction of new surgical principles and primary anastomosis has replaced staged procedures and number of days stay in hospital with caring and with Improvement in field of anesthesia has all contributed to decreasing the morbidity and mortality. About 5 to 15% of cases of severe abdominal pain were due to Mechanical obstruction acquiring sudden onset requiring admission to hospital. Therefore all factors are making difference in outcome of any operative procedure in relation to morbidity and mortality. Patient with acute intestinal obstruction depends largely upon early diagnosis which is useful for success in treatment. Most of the mortality occurs in elderly age with late treatment and who are having associated pre-existing diseases like, diabetes mellitus, COPD and cardiac diseases. However intestinal obstruction is most often the result of colorectal malignancies and lesions usually arise in the sigmoid or recto sigmoid area. Aim: The main aim of this study is to explore different modes of presentations of intestinal obstruction in different age group. Material and method: All patients are informed consents. Total 50 patients having intestinal obstruction with various problems were taken in this study attending to hospital as in patient department (IPD) and outpatient department (OPD) of our hospital. A clinical study of intestinal obstruction were selected has to come across this surgical emergency and treatment and skillful management in surgery department of our hospital. The patients with age group 0-80 years were included in this study. Result: In this study of 50 cases of intestinal obstruction was studied during period of 1 year. The study was done in all age groups with a mean age of 35 years. Occurrence of intestinal obstruction was common in male (72%) as compare to female (28%). Maximum presenting symptoms in this study was pain abdomen (...