Goal: To describe the clinical management of chemotherapy in geriatric patients carried out by nurses of a hospital accredited at the level of excellence in Brazil. Methods: This is a descriptive study of a qualitative nature, of the type of experience report, about the clinical management of chemotherapy in geriatric patients performed by Nurses. Results: There are three nuclei of meaning for a better interpretation and perspective of the study "Nursing Assistance in Geriatric Oncology "," Clinical Management of Chemotherapy Performed by Nurses" AND "Nurses' Performance in an Accredited Hospital at the Excellence Level in Brazil". Conclusion: It is pointed out that the nurses of the service are able to carry out the clinical management of chemotherapy in geriatric patients, regarding the availability of materials and equipment of quality of the service, as a facilitating tool in the care process.