Abstract:Background: Rheumatoid

Materials and MethodS: The analgesic effect of Ondansetron and Aspirin was evaluated in swiss albino mice(n=8). The methods used to produce pain models of animals were chemical method(by intraperitonial injection of .6% of acetic acid) , mechanical method(by tail clip method) and radiant heat method(by analgesiometer). Results: The analgesic effect of Ondansetron was found to be more than Aspirin in chemically induced pain models (P < 0.05.) Aspirin has better analgesic effect than ondansetron in mechanically induced pain (P< 0.05). Ondansetron has no analgesic effect in pain induced by radiant heat method while aspirin is a good analgesic in this method. Conclusion:Ondansetron showed superior analgesic effect than that of aspirin in chemically induced pain .

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