There are numerous studies investigating the effectiveness and potential clinical applications of Spirulina in treating several diseases. So, the present essay was designed to Cultivate Spirulina sp. in three different media; namely (modified commercial low cost Zarrouk medium (MS), Khul medium and Sea Water enriched medium), to compare Biomass concentrations (g/lDW) and optical density (OD) for 20 days, and phytochemical screening (Total phenolic, total flavonoids and Antioxidant activity) of the crude extract of all media with commercial Spirulina (dry product). In addition, examine possible potentials of Spirulina against hepatic intoxication induced by CCl4 in albino male mice. Results revealed that, methanolic extract recorded the highest values in modified Zarrouk's medium (88.98 mg gallic acid equivalent/ml, 78.57 mg Rutin equivalent/ml and 82.04%) in Total phenolic, total flavonoids and Antioxidant activity respectively. Conclusively, Spirulina showed an ameliorating effect of CCl4 induced chromosomal aberrations of bone marrow cells; which proves the protective role of it against the chromosomal damage.

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