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Background: Noise is a modern life wide-spread stressor produced by urban traffic and the industrial environment. The noise stress causes central nervous system’s dysfunction and neurotransmission impairment in the brain, as well as changes the hormones levels which potentially result in psychological and behavioral problems. Underscoring the implications of the chronic stress, the aim of our investigation was to study the level of the malondialdehyde (MDA) in the plasma and erythrocytes’ membrane (EM), as well as the behavioral characteristics of experimental animals, and the influences of the α2-adrenoblockers to evident their modulating effect during noise exposure. Results: The obtained results imply increase of plasma and erythrocytes’ membrane MDA content which is an indicator of oxidative stress development. At the same time the noise impact decreases cognitive functions. Conclusion: The use of α2-adrenoblockers to the noise-exposed animals by the specific tests revealed a regulatory effect on the noise time-dependent delay in behavioral activity manifested by disorientation, increased anxiety, the spatial memory deficit. Reduction of the noise impact by α2-adrenoblockers was expressed by less level of MDA in the EM, in the 3rd and the 4th groups.

Background NADPH oxidase (Nox) plays a crucial role in reactive oxygen spices (ROS) production and mediates different diseases’ development. Under aerobic conditions, the NADPH-containing protein component of the (NCP)-Fe (III) complex produces O2− continuously and intensively. However, after the removal of Fe (III), the isolated NCP shows only antioxidant properties at the expense of NADPH composite. Based on the fact that the mentioned fruit juices are widely used in everyday life and also in biomedicine, it was aimed to use a universal method: 1. to obtain superoxide generating complex from available and relatively cheap raw materials without using any toxic substances; 2. to isolate, purify and study the components of prooxidant nature: the isoforms of O2−—producing NCP-Fe (III) complexes obtained from Armenian fruits (raspberries, apricot, grapes), as well, grape seeds. Results Using a licensed method, for the first time isoforms of the superoxide (O2−) producing a thermostable complex of the NCP component with Fe (III), (NCP-Fe (III)), were isolated and purified from Armenian fruits—raspberries, apricots, grapes, and grapes seeds. The process of isolation and purification of isoforms of these complexes included the following stages of processing: 1. alkaline hydrolysis at pH9,5; 2. their sedimentation at pH4.8; 3. Dissolving of the sediments in water at pH9.5, followed by ion-exchange chromatography on cellulose DE-52, and gel filtration on Sephadex G-100. Further, the heat treatment of the mentioned complexes was carried out. In a lyophilized state, under the anaerobic conditions, the isoforms of the given complexes, hybrid associates (hNCP-Nox), and NCP were stored practically without losing their activity in a mass of 1–1.5 g. Conclusions Isoforms of O2− -producing complexes are new liquid-phase, thermo-stable prooxidant components found in raspberries, apricots, grapes, and grapes seeds.