Ein NO‐vum: Ein Kupfer(I)‐β‐diketiminat aktiviert das Nitrosamin Ph2NNO unter Bildung eines seltenen, dreifach koordinierten Kupfer(II)‐amids, 1. Die Reaktion dieses Amids mit NO‐Gas setzt Ph2NNO wieder frei und liefert eine gemischtvalente Spezies mit NO‐funktionalisierten β‐Diketiminatliganden (2; Cu hellblau, N dunkelblau, O rot). Somit können an einem gewöhnlichen Kupferzentrum Spaltung und Bildung der R2N‐NO‐Bindung gleichermaßen stattfinden.

Communication involving persons with cognitive impairment (CI) associated memory issues requires particular attention in the clinical setting due to the sensitive and often difficult institutional work that must take place between the patient and his or her physician. An individual with CI is often tested for memory issues during the office visit, generating a potentially face-threatening situation. Said individual may attempt to preserve positive identity or ‘save face’ (Gumperz, 1982) by using communicative coping behaviors (CCBs). This study characterizes the use of CCBs (e.g., accounts and humor) by persons with CI in clinical interviews and provides important insight on how to improve doctor—patient communication involving people with CI. In order to describe and compare CCBs used by persons with cognitive impairment, and those used by cognitively normal individuals, verbatim, in-office transcripts from both groups were analyzed. Results showed that participants with CI used more memory accounts than cognitively normal individuals and similar amounts of humor in order to save face and construct a normal identity. These data help to inform doctors and caregivers regarding the ways in which persons with CI construct and preserve a positive sense of self-identity through communication.

A NO‐velty: A copper(I) β‐diketiminate activates the nitrosamine Ph2NNO to give a rare, three‐coordinate copper(II) amide, [(Me2NN)CuNPh2]. Reaction of this amide with NOgas returns Ph2NNO as well as a mixed‐valence species with NO‐functionalized β‐diketiminate ligands (see scheme; Cu light blue, N dark blue, O red). Thus, both the cleavage and formation of R2NNO bonds may take place at a common copper center.

The antifungal armamentarium has expanded greatly over the past two decades. This expansion, along with the pharmacologically complex therapeutic regimens used in treating many patients with systemic fungal disease, enhances the risk of clinically significant drug-drug interactions. This review examines the drug-drug interaction potential of antifungal agents by pharmacologic class and attempts to provide perspective on the time course and clinical significance of these events.

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