Background: Acute pancreatitis (AP) was the most common discharge diagnosis of gastrointestinal disorder that places a substantial burden on the healthcare system. The clinical course of most patient with AP is often mild and it often resolves without sequelae. And yet a considerable percentage of people develop severe AP (SAP) that would greatly affect the outcome. The objective of the current study is to assess the value of neutrophil-lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in prediction of SAP.