Reviewing the current literature for the importance of the plant Albizia lebbeck L. growing worldwide revealed many biological interests. However, the species growing in Saudi Arabia has not received due attention. The present study was undertaken to study antipyretic, analgesic, estrogenic and anti-inflammatory activities of five different fractions from successive extraction of Albizia lebbeck flowers: n hexane, dichloromethane, ethyl acetate, n-butanol as well as the 70% total alcohol. The flowers showed reasonable antipyretic, analgesic, estrogenic and anti-inflammatory activities.