Infectious lymphadenitis in small ruminants which caused by broad ranges of microorganismsis worldwide distributed disease, that subsequently causing significant economic losses to animal production industry. Clinical cases of ovine lymphadenopathy in Awasi sheep are described in this research. These cases were recorded separately in the animal's farm of College of Agriculture, University of Basra / Iraq during November 2017. A 2-4year-old Awasi sheep weighing 30-40 kg, presented to the Large Animal Clinic, College of Veterinary Medicine, University of Basra with an enlargement of superficial lymph nodes. Surgical removals of the affected lymph nodes were done and samples were processed to histopathological and bacteriological examinations. The sheep were tentatively diagnosed with Infectious lymphadenitis. The present study revealed that the infectious lymphadenitis in Awasi sheep were caused by Pseudomonas aeruginosa and the infected sheep might provide evidence for disease transmission and source of infection in the farm as well as human.