A facile one-pot and four-component economical synthesis of pyrido[2,3-d:6,5-d]dipyrimidines using aldehyde, 2-thiobarbituric acid and ammonium acetate in the presence of magnetically heterogeneous catalyst under ultrasonic irradiation in water is described. The present synthesis shows attractive characteristics such as; the use of magnetically recoverable and reusable catalyst, convenient one-pot operation, short reaction periods, high to excellent yields and the use of water as a green reaction medium, mild reaction conditions and is considered to be relatively environmentally benign.

In this study, the one-pot four-component reaction of aromatic aldehyde, 2-thiobarbituric acid, ammonium acetate in the presence of a catalytic amount of [H-NMP][HSO] under ultrasonic irradiation in water is reported. In the present procedure, the pyrido[2,3-d:6,5-d']dipyrimidine derivatives were purely produced as valuable products. The process proved to be simple, environmentally friendly, efficient and high to excellent yielding. Moreover, some of the synthetic compounds were investigated and revealed important antimicrobial activity of prepared products.

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