Our study demonstrated that a high MHR value is an independent predictor of 30-day mortality in patients with AIS.

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Decreased adropin levels were found in the nocturnal hypertensive and non-dipper groups. Adropin and hsCRP were found to be independently associated with a non-dipping pattern. We suggest that decreased levels of adropin in non-dipper hypertensive patients might be associated with a longer duration of exposure to high BP. These results point to a possible future role of adropin in identifying hypertensive patients at higher risk of target organ damage.

Background/aim: Multiple sclerosis (MS) is a common neurological disorder that can be a leading cause of nontraumatic disability in several countries. Recent reports have indicated a moderate to high risk of MS in European countries. In this study, we examined the prevalence of MS in a well-defined urban population of provincial center in Sivas Province in Turkey. Materials and methods:This study sampled all registered residents of urban areas of provincial center in Sivas Province in April 2017 and 2018 January. All the included patients met the McDonald 2010 criteria. Medical records were reviewed, including all available previously acquired magnetic resonance imaging data. All patients were subsequently subjected to neurologic examination to confirm the MS diagnosis. Results:We identified 21 possible MS patients, with MS diagnosis confirmed in 19. The prevalence of MS was 288 per 100,000 inhabitants. Conclusion:For future studies, these high ratio results can be used in regional and national comparisons to determine cofactors contributing to the high prevalence of MS in our region and can help health-decision makers to better plan healthcare policies to improve neurological services and awareness about multifaceted clinical presentations of MS.

SUMMARYObjective: Mean platelet volume (MPV) and platelet distribution width (PDW) are parameters that indicate platelet volume. It is assumed that large platelets are enzymatically and metabolically more active than small platelets. The relationship between elevated MPV and PDW values and arterial thrombosis has been demonstrated, but their roles in venous thrombosis are not fully understood. While the platelet / lymphocyte ratio (PLR), which is considered to be an inflammatory indicator, is known to be associated with many diseases, there are only a few studies in venous thrombosis. For this reason, our aim in this study is to establish the relationship between MPV, PDW and PLR values and cerebral venous sinus thrombosis (CVST). Method: Our study included 54 patients who were diagnosed with CVST in our clinic between January 2008 and September 2016, and 50 controls with similar age and sex. The patients and control groups were compared in terms of MPV, PDW and PLR values. In addition, the patient group was divided into two groups, according to parenchymal brain lesions, and the effect of MPV, PDW, and PLR on prognosis was also assessed. Results: While the MPV, PDW and PLR values were higher in the patient group compared to the controls, there was no significant difference between patients with and without parenchymal lesions. In addition, as MPV and PDW values for CVST development were determined as significant independent variables, optimal cut-off values were identified 8.85 for MPV, 15.75 for PDW and 168.53 for PLR in ROC analysis. Conclusions: As a result, MPV, PDW and PLR values were higher in patients with SVST than controls, however their prognostic significance was not determined. In addition, we may suggest that higher MPV and PDW values are new independent risk factors for CVST development. Keywords: Mean platelet volüme, Platelet distribution width, platelet / lymphocyte ratio, cerebral venous thrombosis ÖZET Amaç: Ortalama platelet hacmi (OPH) ve platelet dağılım genişliği (PDG), platelet hacmini gösteren parametrelerdir. Büyük plateletlerin küçük plateletlere kıyasla enzimatik ve metabolik olarak daha aktif kabul edilmektedir. Artmış OPH ve PDG değerleri ile arteryel tromboz arasındaki ilişki gösterilmiştir ancak venöz trombozdaki yeri tam olarak bilinmemektedir. İnflamatuar bir gösterge kabul edilen platelet/ lenfosit oranının artışının(PLO) birçok hastalıkla ilişkisi bilinmekteyken venöz trombozda kullanımı ile ilgili az sayıda çalışma mevcuttur. Bu nedenle bu çalışmamızdaki amacımız OPH, PDG ve PLO değerleri ile serebral venöz sinüs trombozu(SVST) arasındaki ilişkiyi ortaya koymaktır. Yöntem: Çalışmamıza retrospektif olarak Ocak 2008-Eylül 2016 tarihleri arasında kliniğimizde SVST tanısı ile izlenmiş 54 hasta ile benzer yaş ve cinsiyete sahip 50 kontrol dahil edildi. Hasta ve kontrol grubu OPH, PDG ve PLO değerleri açısından kıyaslandı. Bunun yanında hasta grubu kendi içinde beyin parankimal lezyonu olan ve olmayanlar olarak ikiye ayrılarak OPH, PDG ve PLO'nun prognoz üzerindeki etkisi de değer...