Key words: chronic kidney disease (CKD); creatimine clearance (CrCl); cock croft-gault (CG) formula; modification of diet in renal disease (MDRD) equationDOI: 10.3329/jcmcta.v21i1.7665 Journal of Chittagong Medical College Teachers' Association 2010: 21(1):18-22

The data were collected by a structured questionnaire including age, socioeconomic condition, gravida, para , blood pressure, BMI, FBS, PPBS & Family H/O diabetes mellitus. Patients suffering from shortened red blood cell life span, sickle cell disease or any other condition that could result in premature red blood cell death and longer red blood cell life span, such as vitamin B12 or folate deficiency were excluded. Total 110 pregnant women were included in this study. Among them 70 were considered as case (whose FBS &PPBS according to ADA criteria of FPG value of ³5.3mmol/l and the WHO criteria of a 2-h PPPG value of ³7.8mmol/l) and 40 were considered as control (whose FBS <5.3mmol/L & PPBS <7.8mmol/L). HbA 1c were measured in all sample. Results: Study showed that HbA 1c ( 6%) were more increased in GDM patients than that of the normal pregnancy ( (6.95±1.38% Vs 5.05 ±0.27 %, p<0.001).Result showed that percentage of raised plasma HbA 1C is more in GDM patients than that of the normal pregnancy (57.1%,P=<0.001).Pearson

Keywords: Hypertriglyceridaemia; plasma coagulation factor VII; hypercoagulability; coronary artery diseaseDOI: http://dx.doi.org/10.3329/jcmcta.v22i1.9110 JCMCTA 2011; 22(1): 32-34

Biochemical monitoring of liver function is essential because Anti Tubercular Therapy (ATT) induced hepatotoxicity can cause permanent injury to liver and death. This cross-sectional comparative study was conducted in department of Biochemistry of Chittagong Medical College during the period of July 2009- Jun 2010 to determine the association of Anti-TB treatment to alter the liver function in patients of intensive phase of tuberculosis taking Four Fixed Dose Combination of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol. A total of 100 subjects were enrolled in this study. They were divided into two groups. Group A (case) was diagnosed case of tuberculosis and had taken anti TB drugs (four Fixed dose combination) at least for fifteen days and group B (control) was consisting of normal subjects. Serum ALT, AST, Bilirubin and prothrombin time were measured. It was found, that out of 70 subjects 20% had increased level of serum ALT, 17.1% had increased level of serum AST, 20% had increased level of serum bilirubin and only 2.9% had increased level of prothrombin time in case group. Finally, determination of liver functions in patients receiving Anti TB therapy (in intensive phase) should be done irrespective of presence or absence of established risk factors, to minimize not only the incidence but also the morbidity and mortality. JCMCTA 2012 ; 23 (2): 27-29

The present case control study was designed to determined the relationship between serum Total cholesterol, Low Density Lipoprotein (LDL), Triglycerides (TG) and Body Mass Index (BMI). The study was carried out in the Department of Biochemistry Chittagong Medical College during the period of January 2010- December 2010. Samples were collected from population of different area of Chittagong City Corporation of different occupations, age from 35- 60 years. The data were collected by a structured questionaries which includes age, sex, occupation, dietary habits, family history of hyperlipidemia and DM. BMI was calculated by standardized protocol. Population suffering from DM, renal diseases and other endocrine disease were excluded. A total of 105 subjects were included in this study. Among them 70 were considered as case ( whose BMI was 25 kg/m2) and 35 were considered as control ( whose BMI was < 25 Kg/ m2).Serum Total cholesterol, LDL-C, HDL-C and TG were measured in all samples in fasting state. Study showed that female were more obese than male,( 31.14 +2.23kg/m2 Vs 29.71 +2.69kg/mo), p= <0.05.Results showed that Serum TC(45%), LDL-C(65%), TG(70%) were significantly higher in cases than that of controls (p=<0.001).Serum HDL-C(35%) was significantly decreased in cases than that of controls (p=<0.001).Study showed that hypertriglyceridemia (70%) was the common lipid abnormality and then LDL-C (65%). Study revealed that there was no significant difference in lipid profile between male and female. Pearson's Correlation Coefficient showed that there were positive correlation between TC (r=0.234,p=<0.05), LDL-C (r=0.258,p=<0.01), TG (r=0.409,p=<0.001) and BMI, and was negative correlation between HDL-C(r= -0.403, p= <0.001) and BMI. So early detection and prevention of obesity and abnormal lipid profile can largely reduce morbidity and mortality and alleviate undue burden on our limited health budget. JCMCTA 2012 ; 23 (2): 22-26