Quality of life is regarded as a primary aim in renal failure management, approaching quality of life of patients through an educational program is fundamental and active involvement of patients in their management is an essential component to the overall improvement of their quality of life.The aim: This study aimed to evaluate the effect of an educational program on quality of life for patients with chronic renal failure. Design: Aquasi-experimental research design was utilized. Setting: the study was conducuted at the dialysis unit at 15 May hospital affiliated to ministry of health. Samples: A purposive sample of 50 adult patients from both genders diagnosed with chronic renal failure Tools: Three tools were utilized for data collection Tool (I): Structured interview questionnaire. Tool (II): Knowledge assessment questionnaire. Tool (III): Kidney Disease Quality of Life-Short Form (KDQOL-SF™1.3). Results: 52.0% of studied patient aged from 40-60 years. There were high statistically significant differences of patients' knowledge and quality of life domains as physical, emotional, social and sexual domains with P value (0.000) in comparison to preprogram implementation. There were high statistically significant positive correlations between quality of life and knowledge scores during immediate post and follow up phases (P= 0.000). Conclusions: There was an improvement of patients' level of knowledge regarding care of their disease which leads to improvement of patients' quality of life. Recommendations: The developed educational program should be implemented on a wider scale and evaluated for further improvement.