Diabetes mellitus type II considers as inflammatory disease, which it associated with increasing level of sensitive inflammatory proteins, Adult patients with DM type II may progress a slowly failure of Beta-cells. Some patients show an autoimmune nature of the disease, our Present study aimed toevaluatethe relationship between autoantibodies which includes islet cell antibodies and insulin autoantibodies along with some inflammatory sensitive proteins like Ceruleplasminand Transferrinin type II diabetes mellitus of recent onset disease in an Iraqi population. A total of 50 patients with type II diabetes mellitus were studied as well as 31 control healthy individuals,the individuals in each group were divided into sub groups according to the presence of autoantibodies. The present study tested the presence of both autoantibodies against islet cells in both patients and control groups, the results show the presence of at least one type of autoantibodies and the coexistence of two types of autoantibodies where observed in three patients, therefore, the individuals in each group were divided into sub groups according to the presence of autoantibodies. Serum Ceruloplasmin level showed significant increasing between negative patients group and negative control group, but this increasing is non-significant between positive patients group and positive control group. Positive control group showed significant increasing in serum Ceruloplasmin level compared to negative control group and thatincreasing made serum Ceruloplasmin level in positive control group closely related to its level in positive patient group, while positive patient group showednon-significant increasing compare to negative patient group. Transferrin showed non-significant decreasing level in patient group compared with control for both groups of autoantibody. Present results may refer to inflammatory aspects of disease which associated with autoimmunity markers, moreover, the presence of autoantibodies increased the serum Ceruloplasmin level and decreased level of Transferrin even in healthy individuals. Present conclusion could help in the diagnosis and provide protection from developing disease.

The present study aimed to determine the frequency of ABO and Rh blood group antigens among Sabians (Mandaeans) population. This paper document the frequency of ABO and Rh blood groups among the Sabians (Mandaeans) population of Iraq.There is no data available on the ABO/Rh (D) frequencies in the Sabians (Mandaeans) population. Total 341 samples analyzed; phenotype O blood type has the highest frequency 49.9%, followed by A 28.7%, and B 13.8% whereas the lowest prevalent blood group was AB 7.6%. The overall phenotypic frequencies of ABO blood groups were O>A>B>AB. The allelic frequencies of O, A, and B alleles were 0.687, 0.2 and 0.1122 respectively. Rhesus study showed that with a percentage of 96.2% Rh (D) positive is by far the most prevalent, while Rh (d) negative is present only in 3.8% of the total population. The Sabians (Mandaeans) ethnic group showed the same distribution of ABO and Rh blood groups with others ethnic groups in Iraqi population.

Ceruloplasmin (Cp) is one of the acute phase protein, in this review ,we studied the level of ceruloplasmin with copper (Cu) and iron in 90 patients with coronary heart diseas ( those patients are divided into three groups, whom are stable angina , unstable angina and myocardial infarction compared with 30 healthy volunteers) and the roles of them as diagnostic and prognostic tools.The diagnosis was attend by a clinical examination carried out by the consult medical staff in Ibn AL-Nafis hospital. The result: ceruloplasmin recorded a significantly(p

This study was designed to estimate the level of serum alpha -1- antitrypsin in patients with coronary heart disease. Patients were clinically subdivided into stable angina 25 patients, unstable angina30 patients and myocardial infarction 50 patients. A control sample of 30 individuals was matched with patient for age and sex.Non-significant elevation of serum alpha one antitrypsin were noted in MI cases compared to healthy control individuals, even some MI patients showed decreasing level of alpha one antitrypsin, which may return to hereditary alpha one antitrypsin deficiency in Iraqi patients.The Stable angina patients group showed non-significant decrease in alpha one antitrypsin level compared to healthy control, while unstable angina patients group showed significant decrease in alpha one antitrypsin level that will may facilitate developing disease towards MI. All present results need additional studies to be carried out on larger samples of Iraqi individuals and alpha one antitrypsin deficient patients, furthermore, highlighting on the relationship between alpha one antitrypsin and risk of coronary heart disease.

Type 2 diabetes mellitus (T2DM) is a consequence of several interactions between genetic and environmental agentslead to impairment of insulin action or insulin resistance. The present study was designed todiscover the relationship between calpain -10gene (exon8, 14 and 15) andT2DM.A total 150 subjects, 100 patients with T2DM and50 healthy control. These topics were genotyped for (3 exon) of calpain -10 utilizing PCR and confirmed by direct sequencing. In sequence analysis of exon eight has been exposed a match in the amino acid sequencing between T2DM and healthycontrol. But the exon 14 has beendetected 2mutation, the first was (18778 G>A) substitution of the amino acid arginine at site 18778 with lysine, and the frequency rate (20 % ). The second mutation was (18787 C>A) substitution of the amino acid proline at site 18787 with histidine, and the frequency rate (40 % ).Thesequencingexon 15 has been identified one mutation, this mutation was (19690 A>T) substitution of the amino acid serine at site 19690 with threonine, and the frequency rate (46.8 % ).In conclusion, our study has been explained that the variation in exon 14 and 15 of calpain -10 might cause increase susceptibility andmay be linked with type 2 diabetes mellitus.