Objective: The aim of the present study is to describe the epidemiological, histopathological and therapeutic profile of endometrial cancers in the region of Oran. Methods: We conducted a retrospective study by exploring the medical files of 25 female patients diagnosed of endometrial cancer and treated at the level of the EHU November 1, 1954’s medical oncology department in Oran during the period from January 2015 to December 2019. For data collection, we used a structured exploitation sheet to obtain necessary information. Variables were analyzed using SPSS Software Version 20.0. Results: The median age of patients was 59 years with extremes ranging from 42 to 83 years. More than 56% of our patients were over 50 years old, 40% of the patients were nulliparous and 80% postmenopausal. The average age of menarche was 14.09 ± 1.44 years with extremes ranging from 12 to 17 years. The indication for anatomopathological examination was dominated by metrorrhagia (80%). Histopathologically, endometrioid adenocarcinoma was the most common at 75% of cases. We also note that 62.5% were classified in stage I and 37.5% in stage II. Myometrium infiltration was observed in 66.67% of cases. The basic treatment for endometrial cancer remains surgical. Conclusion: At the end of this work, we concluded that this pathology remains essentially that of postmenopausal women. Endometrioid adenocarcinoma was the most common histologic type. This study also revealed many risk factors for endometrial cancer, such as advanced age, hypertension and nulliparity. Keywords: Cancer, Endometrium, Epidemiology, Anathomopathology, Risk factors