Background: The incidence of chronic kidney disease has been increased every year. One of the treatment in these cases is hemodialysis. Hemodialysis can affect physical dan psychological that affect quality of life in patients. This study was conducted to analyze the differences in quality of life based on frequency of hemodialysis on chronic kidney patients in community. Methods: This research uses a cross sectional design and done at 66 sample with the sampling method of purposive sampling. Data collection using Kidney Disease Quality of Life Questionairre (KDQOL) versi 1.3. Results: The result using Kruskall Wallis Test showed there was a difference between quality of life based on frequency hemodialysis in the domain problem list, effects of kidney disease, patient statification, physical function, role limitation due to physical problems, general health, social function, and energy (p value <0.05). Conclusion: In physics component site, patient with hemodialysis once a week has higher score of quality of life than twice weekly and thrice weekly. Whereas,in mental component site, patient with hemodialysis twice weekly has a higher quality of life score than once weekly and thrice weekly.