Spider vein is mostly seen in patients with liver disease, although the underlying problem is sometimes unknown. If spider vein appears on the face, it can affect the self‐esteem and self‐image of patients. Particularly, females are more vulnerable to these complications. Spider nevi are mostly left untreated since they are considered a cosmetic matter; in case of treatment, the procedure is costly with limited satisfaction. Therefore, this study reports the successful treatment of a spider vein case using a microneedling procedure.

Mesotherapy has received public interest for rejuvenation; however, there is inconsistent and inadequate evidence of its efficacy. As aesthetic physicians, we believe the lack of efficacy for rejuvenation may be due to insufficient injection depth. The standards have not been updated for a long time, and thus doing so will provide patients with better results.