Background: Despite recent developments in intensive care for patients with Traumatic brain injury (TBI), the long-term neurological disabilities still exist. MLC901 is Traditional Chinese Medicine and has shown some neuroprotective and neuro regenerative benefits after brain injury in previous animal and human studies and may provide a new therapeutic approach in the treatment of TBI. Accordingly, we conducted this pilot, randomized, double-masked, placebo-controlled study to investigate the efficacy of MLC901 in patients with moderate to severe TBI. Materials and Methods:Patients with a diagnosis of moderate to severe TBI were enrolled. Subjects were randomly assigned to receive either MLC901 or placebo capsules three times per day over 6 months. Evaluation of patients was carried out at baseline, 3 rd month and 6 th month follow-after injury. Modified Rankin Scale (mRS) and Glasgow outcome scale (GOS) were used to examine patients. Efficacy was evaluated by comparing these two scores between the 2 groups at follow-up visits.Results: Eighty-one patients complete 6 months follow up. There was no significant difference between two study groups regarding the demographic features, interval between injury and start of intervention and length of ICU stay. However, functional outcome scales of GOS, MRS at 3 rd and 6 th month post-injury were significantly better in MLC901 group compared to placebo (p<0.05). Conclusion:MLC901 has shown promising efficacy in patients suffering from moderate to severe TBI.

Background: There is controversy about the value of endoscopic methods compared to microsurgical methods in the treatment of challenging colloidal cysts. This study aimed to review the findings of literature which studied microsurgery or neuroendoscopy in the colloid cyst. Methods: An advanced search in PubMed, Science Direct, and Google Scholar databases performed using keywords such as: "microsurgery," "endoscopy," "microsurgery versus endoscopy," and "colloid cysts." Results: Reviewing the findings of related studies showed some differences in sections of surgical management, microsurgery, endoscopy, complete cyst resection, recurrence rate, length of stay, and complications between the two surgical methods in the treatment of colloid cyst. Conclusion: Despite some disadvantages of endoscopy, it seems this method has more privileges than the other methods.