Background: Ecchino coccosis or hydatid cyst disease is a common parasitic disease that is known to affect bothhumans and animals and is an important health problem in poorly developed countries. Objectives: In this histopathological retrospectivestudy, we aimed to evaluate hydatid cyst disease occurring at different sites of body and were diagnosed during last fifteen years inpathology department, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro from January 1996 to December 2010.Study Design: Descriptive retrospective study. Materials: A total of 80 cases of hydatid cyst disease of different organs diagnosed atpathology department LUMHS Jamshoro and retrieved from Histopathological record. Results: Out of these 80 cases, 56 cases (70%)were of liver, 8 (10%) of lung, 5 (6.25%) of ovary. 01 case (1.2%) thyroid, 02 cases (2.5%) submandibular region and 8 (10%) eachoccurring at thigh, forearm, palm, cheek and fronto-temporal region. Majority of cases seen in females and M/F ratio of 1:3.6 and with agerange of 8-65 years. More than 50% of cases were seen between 30-65 years of age. Conclusion: Hydatid cyst of liver was mostcommon site followed by lung. But it can also be included in differential diagnosis of solitary cystic lesions of ovary and thyroid as well.