Patient education is the process of influencing patient behaviour and producing the changes in knowledge, attitudes and skills necessary to maintain or improve health. Health education may be general preventive, health promotion or diseases specific education. With an education system in place, patients will be satisfied with care, patients will be healthier, and will seek medical services less frequently. There is little or no documentation on the practice of patient education at the University College Hospital, Ibadan. The aim of this descriptive study was to explore factors influencing the practice of patient education among nurses at the University College Hospital, Ibadan. Stratified and simple random sampling techniques were used in selecting 200 nurses at the University College Hospital Ibadan. A self-designed questionnaire was used to collect data. Statistical package for social sciences version 15 (SPSS 15) was used in analysing data. The study revealed that the knowledge and practice of patient education among the nurses in University College Hospital was high and the knowledge was found to be significantly associated with its practice (X 2 = 7.89, p = 0.017). The working experience of nurses does not determine whether they practice patient education or not. Almost all the respondents (70% -90%) in this study affirmed that the nurses' experiences, cultural barriers, work place culture, lack of time, heavy workload, insufficient staffing, and the complexity of patients' condition were important factors that influenced the practice of patient education. In conclusion, nurses at the University College Hospital have good knowledge and positive attitude towards patient education but could not practice effectively. A more critical approach in addressing heavy workload, insufficient staffing, among others is needed to improve patient education. Further studies should be carried out on developing nurses' roles as patient educators.