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A simple and efficient one-pot route for the synthesis of novel spiro [indolin-3,3′-1,2,4-triazol] derivatives by 1,3dipolar cycloaddition reaction of nitrilimines and isatin imines under classical or microwave irradiation conditions is described. Spiro heterocyclic compounds possess pharmacological properties such as antimicrobial, analgesic, anti-inflammatory, antimycobacterial, antifungal, antitumor and antiviral activities.