Melanocytes in odontogenic keratocyst (OKC) were studied histopath‐ologically. As a result, melanocytes were observed within the basal layer of lining epithelium in five of 47 cases with OKC, with the overall prevalence being 10.6 per cent. Although no conclusion could be drawn from the present examination as to the origin of melanocytes in OKC, its possible histogenesis was discussed. ACTA PATHOL. JPN. 35: 899–903, 1985.

-We previously reported that social isolation stimulated a stress response leading to increasing plasma corticosterone level and disruption of the hepatic lipid metabolism-related pathway, without changing body and organ weights, in mice after 4 weeks of social isolation stress, compared with the grouped-housing control (5 mice/cage). In this study, we evaluated the effects of social isolation stress for an extended period on physiologic changes in male C57BL/6J mice. Plasma corticosterone was reduced after 13 weeks, indicating mice might adapt to social isolation stress. However, body and visceral fat weights were significantly increased in combination with hepatic hypertrophy, and significant decreases in levels of triglyceride and adiponectin in plasma were observed. In conclusion, it is tempting to speculate that mice exposed to social isolation stress for 13 continuous weeks could be at an increased risk of overweight with hepatic hypertrophy. Our results also imply that physiological changes, at least fatty acid metabolism, under stress exposure might be an important factor when evaluating the chronic effects of environmental chemicals.

Knots are ubiquitous in nature and their analysis has important implications in a wide variety of fields including fluid dynamics, material science and molecular and structural biology. In many systems particles are found in crowded environments hence it is natural to rigorously characterize the properties of knots in confined volumes. In this work we combine analytical and numerical work on the simple cubic lattice to determine the minimal number of lattice steps, minimum step number, needed to make a knot inside a tubular region. Our complementary approaches help us establish a detailed enumeration of minimal knot lengths and/or conformations of knots in tubular regions. Analytical results characterize the types of knots and links that can be embedded in a tubular regions and determines the minimum number of steps required to construct all 2-bridge knots and links up to ten crossings in the (2 × 1)-tube. Simulation results, on the other hand, estimate the minimum step number and provide exact trajectories of all knot types up to eight crossings for wider tubular regions. These findings not only determine what knots and links can be built in a highly confined volume but also provide 7 To whom questions concerning the numerical studies should be addressed. 8 To whom questions concerning the analytical studies should be addressed.

The exorbital lacrimal glands (ELG) of rats were examined for both sexes to determine what degree of harderianization occurred as a function of age and after castration, and to investigate its time course and origin in ELG. Light microscopically, very small Harderian foci were seen in the ELG of both sexes at 3 weeks of age. As the male rats became older, the relative volume of the Harderian gland (HG) cells in the ELG increased. At age 6 months, the value was 1.25 ± 0.31% in males and 0.13 + 0.05% in females (p < 0.05). After castration, a significant decrease (0.21 ± 0.01% p < 0.05) was observed in that of male ELG. In contrast, in female ELG, HG cells were inconspicuous and the relative volume of those did not vary during this experimental period or after castration. It appeared that the HG cells had developed from undifferentiated basal cells of the acini and the intercalated ducts in the ELG at age 2–6 months. Then, at age 22 months, they also probably developed from those of the excretory ducts of the ELG.

Histopathologic study of satellite cysts and odontogenic epithelial islands in connective tissue wall of unilocular type of calcifying odontogenic cyst (COC) was made. The material was 13 cases consisting of 3 simple unicystic COCs, 9 odontome producing COCs and 1 ameloblastomatous proliferating COC. Satellite cysts were found in 6 cases, and were histologically classified into following types: simple cystic, odontome producing and ameloblastomatous. Histologic types of satellite cysts did not coincide with those of main cystic lesions in some cases. Odontogenic epithelial islands with or without proliferating feature were found in 9 cases, and were found in all cases with satellite cysts. Melanin and melanocytes were seen in an ameloblastomatous satellite cysts of 1 of 3 pigmented COCs.