Our findings suggest that GLO1 deficits and carbonyl stress are linked to the development of a certain subtype of schizophrenia. Elevated plasma pentosidine and concomitant low vitamin B(6) levels could be the most cogent and easily measurable biomarkers in schizophrenia and should be helpful for classifying heterogeneous types of schizophrenia on the basis of their biological causes.

Family psychoeducation is effective in the prevention of relapse in adult patients with major depression.

No abstract

Psychotic-like experiences are associated with suicidal feelings and deliberate self-harm behaviors in adolescents aged 12-15 years.Objective: Psychotic disorders are a significant risk factor for suicide, especially among young people. Psychotic-like experiences (PLEs) in the general population may share an etiological background with psychotic disorders. Therefore, the present study examined the association between PLEs and risk of suicide in a community sample of adolescents. Method: Psychotic-like experiences, suicidal feelings, and self-harm behaviors were studied using a self-report questionnaire administered to 5073 Japanese adolescents. Depression and anxiety were evaluated using the 12-item General Health Questionnaire (GHQ). Results: The presence of PLEs was significantly associated with suicidal feelings (OR = 3.1, 95% CI = 2.2-4.5) and deliberate selfharm behaviors (OR = 3.1, 95% CI = 2.0-4.8) after controlling for the effects of age, gender, GHQ-12 score, victimization, and substance use. Suicidal feelings and behaviors were more prevalent in subjects with a greater number of PLEs. Conclusion: Psychotic-like experiences may increase the risk of suicidal problems among adolescents. Significant outcomes• Psychotic-like experiences are associated with suicidal feelings and deliberate self-harm behaviors among adolescents aged 12-15 years.• Suicidal feelings and deliberate self-harm behaviors are more prevalent in subjects with a greater number of psychotic-like experiences. Limitations• This is a cross-sectional study and subjects were recruited from public schools.• A self-report questionnaire was used to assess the psychotic-like experiences, suicidal feelings, and self-harm behaviors.• There was a lack of data about confounding factors, such as individual personality and family circumstances.