We report the development of a new system for C–H functionalizations catalyzed by nickel complexes. The findings show that aromatic amides with a simple directing group can participate in Ni-catalyzed C–H functionalization.
The reaction of N-heteroaromatic compounds, such as 2-aryl-pyrrole, benzimidazole, imidazole, indole, and pyrazole derivatives, with alkynes in the presence of a catalytic amount of a nickel complex results in C–H/N–H oxidative annulation.
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