A 71-year-old man from the Miyako Islands of Okinawa, Japan, had sarcoidosis affecting the peripheral nerves and kidneys. He had been treated with methylprednisolone pulse therapy and subsequently oral prednisolone at a maximum of 50 mg/day (1 mg/kg per day) and azathioprine at a maximum of 100 mg/day, with doses adjusted according to symptoms.Approximately 2.5 months after treatment initiation, under treatment with prednisolone 40 mg/day and mizoribine 150 mg/day, he developed several neck, waist and lumbar nodules. Histological examination showed proliferation of

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Stevens‐Johnson syndrome (SJS) is a rare but fatal disease and is characterized by various clinical symptoms, including acute inflammatory vesiculobullous lesion of skin, oral cavity, ocular surface, genitals, etc Drugs, such as anti‐epileptic drugs, antibiotics, pain killers/antipyretics, and/or bacterial infections have been widely known to cause SJS. Herein, we report a 40‐year‐old man with atypical SJS caused by acetaminophen, which was used for treating an acute odontogenic infection. The patient presented with several risk factors associated with SJS; thus, careful monitoring of the patient's drug history is mandatory to treat acute inflammation in the oral cavity.

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