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We present a comprehensive record of Holocene (11,590–628 cal. yr BP) climate and hydrographic changes around the Wular Lake located in Kashmir Valley, India. Based on the multi-proxy investigations, we have identified three phases of wet climate conditions that prevailed from the commencement of the Holocene Epoch – 9000 cal. yr BP, 8100–6650 cal. yr BP and 6350–5000 cal. yr BP, whereas periods of dry climate were observed during 9000–8100 cal. yr BP, 6650–6350 cal. yr BP and ~5000 to 4000 cal. yr BP. The results also suggested that the lake widened and deepened significantly around 6350–5000 cal. yr BP. The results indicated desiccation and the exposure of the lake margin around 5000–4500 cal. yr BP. The sedimentation rate since 4500–628 cal. yr BP was quite low for detailed paleoclimate interpretations. Oscillations in lake extension and deepening appear to be due to changing intensity of westerly moisture in the region, and we correlate several of the low lake-level phases to the Bond events caused by North Atlantic ice rafting events.

BackgroundMatrix metalloproteinases (MMPs) are enzymes that degrade all the components of extra cellular matrix and collagen. Various types of MMPs are known to be expressed and activated in patients with oral submucous fibrosis (OSMF) as well as head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to asses the association of the single nucleotide polymorphism (SNP) adenosine insertion/deletion polymorphism (-1171 5A->6A) in the MMP-3 promoter region in these lesions.MethodsMMP-3 SNP was genotyped by polymerase chain reaction-restriction fragment polymorphism (PCR-RFLP) analysis in a case control study consisting of 362 participants; 101 cases of OSMF, 135 of HNSCC and 126 controls, compared for age, sex and habits. ROC distribution was plotted to assess the contributions of genetic variation in MMP-3 genotypes with relation to age.ResultsAnalysis of MMP 3 (-1171 5A->6A) polymorphism revealed the frequency of 5A allele in OSMF, HNSCC and controls to be 0.15, 0.13 and 0.07, respectively. A significant difference was found in 5A genotype frequency between OSMF (5A genotype frequency = 0.15, p = 0.01, OR = 2.26, 95% CI = 1.22-4.20) and in controls (5A genotype frequency 0.07) as well as HNSCC (5A genotype frequency 0.13, p = 0.03,95%CI = 1.06-3.51) and controls (5A genotype frequency = 0.07) In this study, 5A genotype had greater than two fold risk for developing OSMF (OR = 2.26) and nearly the same in case of HNSCC (OR = 1.94) as compared to controls. In patients with OSMF as well as HNSCC, the ROC analysis between the MMP-3 genotype and age, 6A/6A allele was found to be significant in patients both over and under 45 years of age; while the 5A/5A carrier alleles showed an association only in patients less than 45 years of age.ConclusionsThis study concluded that the expression of MMP-3 genotype associated with the 5A alleles, it may have an important role in the susceptibility of the patients to develop OSMF and HNSCC.

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