The agro-industry generates a large amount of waste. This waste represents a source of contamination of soil, air, and bodies of water. This represents a problem for the environment as well as for public health. However, this waste is an important source of bioactive compounds, such as phenolic compounds, terpenes, β-glucans etc. These compounds have certain biological activities that are associated with improvements in health. An approach of using these bioactive compounds as food additives for aquaculture have been addressed, where it is sought that organisms, in addition to growing, preserve their health and become disease resistant. The use of agro-industrial waste as a source of bioactive compounds for aquaculture provide an added value to production chains, reduce pollution, and improve the wellbeing of organisms through nutrition. The composition of bioactive compounds of agro-industrial wastes and their application in aquaculture is addressed in this paper.