Because ducks are one of the important poultry in Iraq and due to the important role of the pancreas in the digestive process, this study was conducted to obtain the histological structure of the duck endocrine pancreas with its immunohistochemical study. The pancreas samples were taken from 10 indigenous adult male ducks. The histological study used two stains. Primary and secondary antibodies to the glucagon and insulin hormones were used for the immunohistochemical study. The result of the current study revealed three types of islets (alpha, beta, and mixed islets) in the duck pancreas. Alpha islets consisted of mainly alpha cells with few delta cells, and beta islets contained beta cells and a few delta cells. Also, alpha and beta cells with numerous delta cells were presented in mixed islets. The pancreatic islets are concentrated in the splenic lobe. The immunohistochemical result found the average glucagon intensity in alpha and mixed islets of duck pancreas was (295.3 ± 8.32 megapixel, and 110.2 ± 4.35 megapixel) respectively, and the average insulin intensity in beta and mixed islets of ducks was (265.4 ± 5.14 megapixels, 122.1 ± 3.65 megapixel) respectively.