Groundwater is a vital resource that helps mankind and development. However, in Moroto District challenges of groundwater development has increased arising from changes in rainfall patterns coupled with high abstraction from population increase. In this study, the spatial variability of groundwater potential was assessed to develop a tool that will aid decision on groundwater potential sites selection for groundwater development/exploration. The study utilized an integrated technique and tools such as Remote Sensing (RS), Geographic Information System (GIS) and Multi Criteria Decision Analysis (MCDA) in analysis and delineation of potential areas for successful groundwater development. The generated map through weighted overlay of thematic layers (slope, soil, lithology, rainfall, land use and land cover) produced five categories of potential zones indicating 90% (i.e., 35% very high, 40% high and 15% moderate) of the study area to be suitable for groundwater development and only 10% (i.e., 2% poor and 8% very poor) exists as poor groundwater potential zones. Maps produced from this study can hence be used to identify appropriate sites for groundwater development, and therefore minimizing unsuccessful boreholes development. Keywords:    GIS; Groundwater Development; Groundwater Potential; MCDA; Spatial Analysis.