A key of success in tissue regeneration is the use of a suitable scaff old either to carry specialized cells ex vivo or to orchestrate and diff erentiate the homing of endogenous cells in vivo. This review aims to elucidate the materials that have been studied for dental pulp tissue regeneration/engineering and summarize their properties, advantages, and disadvantages. PubMed databases were searched for engineering, pulp regeneration, endodontics, and stem cells) without time restrictions. The search was restricted to articles published in English language. When necessary, additional searches for the structure, properties and history of the specifi c scaff old materials were achieved. Data from clinical, in vivo and in vitro studies were extracted, classifi ed and reviewed. By providing an overview of possible scaff olds for pulp tissue regeneration, we aim to improve the understanding of the requirements of the clinical application of regenerative endodontics.

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