This is a retrospective study of postmenopausal women admitted with myocardial infarction (MI) in five hospitals (having coronary care unit (CCU) in Kathmandu, Nepal, in 1 year period, from 1st Jan 2001 to 31st Dec 2001. Out of 210 cases admitted in CCU,147 (70%) were suffering from acute MI. Two of the three following criteria were used for the diagnosis of MI: characteristic substernal pain of recent origin more than 30 minutes, elevated cardiac enzymes (creatinine kinase, lactate dehydrogenase, aspirate transaminase), ECG: evidence of infarction (pathological Q waves, ST elevation more than 1 mm in standard lead 1/Avl and/or ST elevation more than 2 mm in precordial leads V1-6 followed by T wave inversion. The major identifiable modifiable risks identified are hypertension in 111 (53.8%), smoking 73 (35.0%), diabetes mellitus in 47 (23.03%), hyperlipidemia in 17 (8.1%), previous coronary heart disease (CHD) in 32 (15.2%) and family history of CHD was present in 2% of the cases. Twenty-two patients (10%) died during treatment and six patients (3%) were readmitted with repeat MI within 6 months of the 1st MI and all recovered well.