Image segmentation is an essential phase of computer vision in which useful information is extracted from an image that can range from finding objects while moving across a room to detect abnormalities in a medical image. As image pixels are generally unlabelled, the commonly used approach for the same is clustering. This paper reviews various existing clustering based image segmentation methods. Two main clustering methods have been surveyed, namely hierarchical and partitional based clustering methods. As partitional clustering is computationally better, further study is done in the perspective of methods belonging to this class. Further, literature bifurcates the partitional based clustering methods into three categories, namely K-means based methods, histogram-based methods, and meta-heuristic based methods. The survey of various performance parameters for the quantitative evaluation of segmentation results is also included. Further, the publicly available benchmark datasets for image-segmentation are briefed.
Tissue engineering technologies involving growth factors have produced one of the most advanced generations of diabetic wound healing solutions. Using this approach, a nanocomposite carrier was designed using Poly(d,l-lactide-co-glycolide) (PLGA)/Gelatin polymer solutions for the simultaneous release of recombinant human epidermal growth factor (rhEGF) and gentamicin sulfate at the wound site to hasten the process of diabetic wound healing and inactivation of bacterial growth. The physicochemical characterization of the fabricated scaffolds was carried out using scanning electron microscopy (SEM) and X-ay diffraction (XRD). The scaffolds were analyzed for thermal stability using thermogravimetric analysis and differential scanning calorimetry. The porosity, biodegradability, and swelling behavior of the scaffolds was also evaluated. Encapsulation efficiency, drug loading capacity, and in vitro drug release were also investigated. Further, the bacterial inhibition percentage and detailed in vivo biocompatibility for wound healing efficiency was performed on diabetic C57BL6 mice with dorsal wounds. The scaffolds exhibited excellent wound healing and continuous proliferation of cells for 12 days. These results support the applicability of such systems in rapid healing of diabetic wounds and ulcers.
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