Acharya Susruta describes about the various stages in the development of malignant tumors and also recognizes recurrence as well as metastasis. The concept of Shatkriyakala, is an objective approach of Ayurveda, which gives a sign about the consecutive phases of the disease for distinguishing the particular disease and to institute appropriate therapeutic intervention, and accordingly preventive measures can be described to overcome complications as well as advancement of the disease. Shatkriyakala, in which disease state is not an instantaneous occurrence, evolves through a sequence of certain phases in relation to the tridoshas-pathophysiologic rhythm. In respect to cancer pathogenesis, it is a hyper-proliferative disorder develops due to genetic dysregulation of growth of cells and tissues that encompasses many stages such as transformation, derange of apoptosis, proliferation, invasion, angiogenesis and metastasis (almost final stage). The physician must acquire the knowledge to recognize early stages of the diseases and accordingly initiate the needful management to contain the further progression of the diseases. In this article critically correlate the concept of Shatkriyakala (stages of progression of disease) in respect to cancer pathogenesis based on the probable involvement of tridoshas (Vata, Pitta and Kapha), Dushyas (dhatus, upadhatus & malas), Agni, Srotas etc.

Acharya Susruta describes about the various stages in the development of malignant tumors and also recognizes recurrence as well as metastasis. The concept of Shatkriyakala, is an objective approach of Ayurveda, which gives a sign about the consecutive phases of the disease for distinguishing the particular disease and to institute appropriate therapeutic intervention, and accordingly preventive measures can be described to overcome complications as well as advancement of the disease. Shatkriyakala, in which disease state is not an instantaneous occurrence, evolves through a sequence of certain phases in relation to the tridoshas-pathophysiologic rhythm. In respect to cancer pathogenesis, it is a hyper-proliferative disorder develops due to genetic dysregulation of growth of cells and tissues that encompasses many stages such as transformation, derange of apoptosis, proliferation, invasion, angiogenesis and metastasis (almost final stage). The physician must acquire the knowledge to recognize early stages of the diseases and accordingly initiate the needful management to contain the further progression of the diseases. In this article critically correlate the concept of Shatkriyakala (stages of progression of disease) in respect to cancer pathogenesis based on the probable involvement of tridoshas (Vata, Pitta and Kapha), Dushyas (dhatus, upadhatus & malas), Agni, Srotas etc.

According to the latest data, globally 15% of couples have infertility and male infertility contributes to 10% of all cases. Infertility can be caused by certain biological changes in the gonads and the reproductive system like azoospermia, oligospermia, asthenospermia, teratozoospermia and hypospermatogenesis. Genetic causes of azoospermia include chromosomal abnormalities, Y chromosome microdeletions and deletion or other mutations of Y-linked genes. The maximum number of the genes are located in the azoospermia factor region of the long arm (Yq) of the Y chromosome. Y chromosome microdeletion is known as the second major genetic cause of spermatogenetic failure. This article aims to review the latest updates on the involvement of Yq microdeletions in male infertility. The diagnostics, prevalence and phenotypic spectrum related to Yq gene microdeletions are discussed.