In this research, six neonicotinoid
analogs derived from l-proline were synthesized, characterized,
and evaluated as insecticides
against Xyleborus affinis. Most of the target compounds
showed good to excellent insecticidal activity. To the best of our
knowledge, this is the first report dealing with the use of enantiopure l-proline to get neonicotinoids. These results highlighted the
compound 9 as an excellent candidate used as the lead
chiral insecticide for future development. Additionally, molecular
docking with the receptor and compound 9 was carried
out to gain insight into its high activity when compared to dinotefuran.
Finally, the neurotoxic evaluation of compound 9 showed
lower toxicity than the classic neonicotinoid dinotefuran.
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