Warts are benign epithelial proliferations of the skin and mucous membranes caused by human papilloma viruses (HPVs). Plane warts are mainly caused by HPV-3 and HPV-10. There is no absolute effective single treatment, and multiple treatment modalities may be combined. One must take into consideration the probability of spontaneous regression, and so the therapeutic approach should not be too aggressive. We report a case of 11 years immunocompetent child presenting with recalcitrant multiple plane warts who was successfully treated with intralesional 2% zinc sulfate solution injection in one lesion after a failure of many other treatment modalities. Our case may represent a starting point for further studies to evaluate the best dose used for management and to avoid any side effects. Intralesional zinc sulfate injection could be a promising treatment option for plane warts. K E Y W O R D S infection, bacterial/fungal/viral, warts 1 | INTRODUCTION Warts are benign epithelial proliferations of the skin and mucosa caused by infection with human papilloma viruses (HPVs). Although many treatment modalities are available, treatment can be difficult. | CASE REPORTAn 11-year-old child presented to our outpatient dermatology clinic with a complaint of multiple skin-colored papules on his face for 18 months. He was; otherwise, in a good health as determined by medical history and physical examination. On local examination, there were numerous plane warts on his forehead. A diagnosis of plane warts was made clinically and confirmed dermoscopically. Multiple therapies have been tried, including cryotherapy, electrocauterization, topical retinoids, purified protein derivative, and candida immunotherapy, however the lesions persisted despite the repeated treatments (recalcitrant warts). Three months after failure of these treatment lines, we decided to try the treatment with intralesional 2% zinc sulfate. The patient was injected with 2% zinc sulphate intralesionally at a single lesion till blanching occurred.The solution was prepared by dissolving 2 g of zinc sulfate powder in 100 ml of sterile distilled water. Then the solution was autoclaved at 95 C for 20 min. The patient came back after 2 days with an intense local inflammatory reaction in all lesions and he was prescribed a NSAID. The skin lesions showed total clearance 1 week after the first injection, but unfortunately, there was a textural change at the site of injection. There was no relapse after a 6-month follow-up.