Abstract. Over the past decade, China has been one of the fastest-growing tourism source markets in the world. The volume of Chinese outbound travelers has grown from 10 million in 2000 to 83 million in 2012. However, the growth of outbound tourists increases the likelihood of the spread of communicable diseases which significantly influence tourism industry. The evidences can be seen from the Foot-Mouth Disease in UK and SARS in China. This paper proposes a framework of disease monitoring system for outbound tourism by analyzing the direction of tourists flow, the transmission of information flow, and the connection between information flow and tourists flow. In addition, the necessary factors that ensure a successful operation of the disease monitoring system are discussed.