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Purpose: To assess the relation between serum creatinine level in pregnant women and correlation between its value and occurrence of preeclampsia. Methods: An 80 pregnant female were involved in the study. They were divided into 40 case group; pregnant females with risk factors of preeclampsia and 40 apparently healthy pregnant women as a control group. Serum creatinine was tested using auto-analyzer, using the commercially available kits. Results: Serum creatinine was significantly higher in women who developed preeclampsia later. Conclusion: In summary we found an association of serum creatinine and preeclampsia. we recommend to use serum creatinine test in screening in women who are at risk of having preeclampsia later in pregnancy.

Purpose: To assess the relationship of factor V leiden G1691A mutation as a risk factor for repeated pregnancy loss. The focus has been on factor V leiden G1691A mutation that may predispose women to microthrombosis during the stages of embryo implantation and placentation. Methods: A total of 70 women with recurrent pregnancy loss, mean age 31.1±4.2 years, were involved in the study. As a control group, 70 women [mean age 32.2±3.3 years with at least two live-born child and no history of abortion were included. We used real-time polymerase chain reaction (PCR) to determine the frequencies of factor V leiden G1691A genotype. Results: The frequency of heterozygotes for factor V leiden G1691A was significantly higher in women with repeated pregnancy loss compared to women without abortion (p = 0.0001). Conclusion: In summary we found an association of factor V leiden G1691A mutation with recurrent pregnancy loss .We recommend for factor V leiden G1691A screening in cases with repeated pregnancy loss so they can start anticoagulant therapy more earlier.

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Background and objectives:The aim of the present study is to evaluate and compare IgG-binding to megakaryocytes in bone marrow of ITP and MDS patients to determine megakaryocytes targeting by autoantibodies in vivo as a mechanism of platelet underproduction in these disorders. Subjects and methods: The study was carried out on 20 ITP (group I) patients and 20 thrombocytopenic patients with myelodysplastic syndrome (group II) who were admitted to minia university hospital. Serial histological sections from bone marrow biopsies were stained for IgG. Results: high IgG binding was found in ITP and MDS patients (group I & II ) and there was no statistically significant difference between both groups ((14/20 (70%) vs. 13/20 (65%),), (P value =0.736). Conclusion: Antibody binding to megakaryocytes in a proportion of MDS patients suggests that immune mediated mechanism underlies PLT underproduction in those patients