Tumour Lysis Syndrome (TLS) is an important oncological emergency case which is often found together with haematological malignities and, much less often, with solid tumours. While TLS seen in solid tumour cases usually develops following a cytotoxic chemotherapy and its prognosis is poor. We present the case of a 60-year-old man with gastric adenocarcinoma with diffuse liver metastases (image shows diffuse liver metastatic lesions) and high serum LDH levels, who developed TLS after systemic chemotherapy. With urgent and proper supportive treatment (intravenous intensive hydration, sodium bicarbonate, diuretic, calcium gluconate, allopurinol and haemodialysis), an impressive recovery from TLS was achieved in the patient with an advanced stage gastric cancer. The purpose of this report is to emphasize that although the present case was a rare, high physician attention is required because significant morbidity or mortality may occur when the syndrome is not duly considered during the pre-cytotoxic evaluation of the patient, when preventive measures are not taken, or if the appropriate treatment is not applied immediately once the syndrome appears, especially in patients who have high tumour burden solid cancer.

Inflammatory myofibroblastic tumor is a borderline neoplasm with uncertain malignant potential. The most frequent site of localization is the lungs. The localization in larynx in the head-neck area is rather rare. The 11-year-old female patient had the symptom of hoarse voice, which had been continuing for three years. The laryngoscopy performed showed a polypoid tissue with a wide base, which involved the left vocal cord at full length. The polypoid tissue was completely excised. The histopathological examination performed demonstrated several myofibroblasts with intranuclear pseudoinclusions, which were surrounded by mixed inflammatory infiltrates in a myxoid stroma. No significant atypia, mitosis and necrosis were observed. The immunochemistry stains were positive for Vimentin, ALK and EMA in neoplastic cells. Alcian blue stain was positive in the myxoid stroma. The case was diagnosed with laryngeal inflammatory myofibroblastic tumor in the light of histopathological and immunohistochemical findings. Laryngeal inflammatory myofibroblastic tumor, a rare entity, should definitely be distinguished from malignant laryngeal tumors. Accurate diagnosis ensures that unnecessary and aggressive treatment methods are avoided and complete, organ-salvaging resection adequate for the inflammatory myofibroblastic tumor be conducted. J Clin Exp Invest 2015; 6 (3): 315-317

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GirişTüm over malignensileri içinde seks kord stromal tümörlerin oranı %5-8'dir (1). Seks kord stromal over tümörlerinin yaklaşık %70'ni oluşturan granüloza hücreli tümörler her 100.000 kadının 0.4-1.7'sinde görülür (2). Granüloza hücreli over tümörleri seks kordlarından ve over stroma veya mezenkiminden köken alırlar. Tümörün başlangıç yaşı ve histolojik özelliklerine göre bu tümör adult ÖZET Amaç: Granüloza hücreli tümörler (GHT), overin epitelyal tümörlerine kıyasla nadir görülen daha iyi prognozlu düşük gradeli ve seks kord stromal kaynaklı tümörleridir. Tüm over kanserlerinin yaklaşık %5-8'ini oluştururlar. Biz bu çalışmada, kliniğimizde overin granüloza hücreli tümörü tanısıyla takip edilmiş olan hastaların klinik ve patolojik özeliklerini araştırdık. Results: FIGO staging is used for clinical staging of patients. The median age of patients was 45 (21-62). Of patients, while 14 of them were adult type subtype and the other two of them were juvenile subtype. In the macroscopic examination, the average tumor size 7 cm (2-20 cm). In all of the patients % 68 was premenopausal. The most common symptom was abdominal mass. In this study, the rate of mitosis phase, cellular atypia situations beyond surgery was evaluated in terms of other important prognostic factors. Endometrial proliferation was not detected in none of our patients. Adjuvant chemotherapy was given to 3 of them. Recurrence or metastasis was not observed during the follow-up period. Conclusion:The prognosis of ovarian granulosa cell tumors are quite good and they have very low risk of tumor recurrence. Treatment decisions should be taken by a multidisciplinary team. Patients themselves should be included in the decision-making process with regarding type of treatment