There is a preference for natural food products and functional food ingredients, which are believed to benefit human health and exist inherently in foods, instead of receiving compounds chemically synthesized. Moreover, to strong immunity system is among people's highest priority in a post-pandemic era as the Covid-19 pandemic caused the catastrophic effects. In particular, bioactive extracts or single functional food components that can prevent nutrition-related diseases have huge importance for human nutrition and promote the human immune system (Galanakis, 2021). In this context, finding alternative, cheap, natural, and sustainable food resources such as macroalgae, duckweed, and insects for bioactive compounds is one of the trend research topics.Macroalgae are renewable sources that live in the marine ecosystem and are excellent for human nutrition, also have an important commercial potential as a functional ingredient in a variety of foods (Cofrades et al., 2017;García-Vaquero et al., 2017). In particular, proteins as one of the essential nutrients isolated from macroalgae have various bioactive properties such as antioxidant, anticancer,