Nosocomial infectious diseases are caused by Staphylococcus aureus bacteria. Treatment of infection can use drugs in the form of substances produced by a microorganism in the form of antibiotics. However, the problem that often arises with antibiotics is the occurrence of resistance. Alternatives that are able to overcome the problem of antibiotic resistance against bacteria are plants that have antibacterial activity, one of which is kaliasem (Syzygium polychephalum). This study aims to determine the compounds contained in the ethanol extract of the bark of kaliasem (Syzygium polychephalum) and to determine the potential of its activitiy on the growth of Staphylococcus aureus in vitro. The bark extract of kaliasem (Syzygium polychephalum) had been carried out by using maceration method. Determination of antibacterial activity was carried out by the disc diffusion method. The ethanolic extract of the bark of kaliasem (Syzygium polychephalum) contains antibacterial compounds such as tannins, phenolics, terpenoids, alkaloids and flavonoids and the ethanolic extract of the bark of kaliasem (Syzygium polychephalum) at concentrations of 25%, 50%, 75% and 100% can inhibit growth of Staphylococcus aureus bacteria with an average inhibition zone of 15.85 mm, 18.36 mm, 23.64 mm, 28.58 mm, respectively. Therefore, it can be concluded that the ethanolic extract of the bark of kaliasem (Syzygium polychephalum) contains antibacterial compounds and has the potential to inhibit the growth of Staphylococcus aureus bacteria.

Background: The COVID-19 pandemic is an infectious disease that has spread worldwide. Prevention of COVID-19 can be suppressed with a good level of knowledge and positive attitudes and behaviors. The community needs to play a role in breaking the chain of transmission of COVID-19 by implementing health protocols. The purpose of this study was to determine the relationship between the level of public knowledge about COVID-19 and the attitudes and behavior of the people of Denpasar City towards obesity, which are more susceptible to infection with COVID-19. Method: This type of non-experimental research with correlational design and cross-sectional design. The number of samples in this study was 400 respondents using simple random sampling. Data collection uses a questionnaire via WhatsApp with a google form. Results: The results showed that there was a relationship between public knowledge about COVID-19 and the attitudes and behavior of the people of Denpasar City towards obesity being more susceptible to infection with COVID-19 with p = 0.000 and r = 0.307 for attitudes and p = 0.000 and r = 0.408 for behavior. Conclusion: A strong correlation between the variable level of knowledge and attitudes and behavior and the direction of the relationship is positive, which means the better the level of knowledge, the better the attitude and behavior of the community to prevent contracting COVID-19.