Because of the vast use of statins to control and treat hyperlipidemia, this study was set to compare the most common statins Atorvastatin and Simvastatin with the flavonol Kaempferol considering the unwilled collateral effects of them. Sixty adult albino male rats were allocated into five groups of twelve members to each. It is obvious based on the results that Atorvastatin could cause significant declination in the hemoglobin, hematocrit, platelets and leukocytes while simvastatin could cause a significant declination in leukocytes and platelets, on the other side; the kaempferol could not affect these values comparing with the control group. The lipid profile and the hepatic enzymes like Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) were significantly disturbed too in all groups and it was very clear that serum aminotransferases and alkaline phosphatase were significantly elevated in all groups except the Kaempferol comparing with control group at (P≤0.05). It is very obvious that kaempferol could ameliorate the lipid profile the antioxidant enzymes and the blood values in a manner which is better than those of statins.