The study investigated the performance of the students in Chemistry using computer-aided instruments using a quasi-experimental method with a pre-post-tests control group design. A total of one hundred ninety-one (191) grade 7 students were selected as respondents to the study. Students in the experimental group were exposed to computer-aided instruments, while students in the control group were exposed to traditional instructions. The findings reveal there was a highly significant difference between the performance of the experimental and that of the control group. Moreover, it is suggested not to use a single strategy, method, approach, or technique in delivering instruction to address the need of today’s mixed-ability classroom. It is recommended to include computer-aided instructions in the In-Service Training of the teachers and conduct a series of seminars on the different elements of this approach to have a deeper understanding and have a better idea of how computer-aided instruments are best used in the teaching and learning process.