Posterior reversible encephalopathy syndrome (PRES) is an entity characterized by the presence of variable neurological symptoms and reversible edema typically affecting the posterior white matter on brain MRI studies. It has been described in association with autoimmune diseases and with the use of chemotherapy and immunosuppressive drugs. We report a case of a 58-year-old woman with Behcet's disease treated with methotrexate, adalimumab and lowdose prednisone who presented with sudden bilateral visual loss, together with radiological findings and clinical course suggesting PRES. PRES may appear associated with Behcet's disease, from whose neurological complications should be differentiated, since management and prognosis differ significantly.